Drug eruption - Letusan Ubar
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Letusan ubar (Drug eruption) dicirikeun ku mangaruhan sakabéh awak.
relevance score : -100.0%
ReferencesRéaksi kulit anu disababkeun ku nginum obat, disebut bitu ubar, kadang tiasa parah. Réaksi parah ieu, disebut severe cutaneous adverse drug reactions (SCARs), dianggap ngancam kahirupan. Éta ngawengku kaayaan sapertos Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), sareng drug reaction with eosinophilia and systemic symptoms (DRESS). Sanajan SCARs jarang, kira‑kira 2 % pasien anu dirawat di rumah sakit ngalamanana.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Wanoja umur 31 taun nganjang ka departemen dermatologi kalayan bintik beureum anu teu nyeri di luhur suku katuhuna. Anjeunna parantos nyandak hiji dosis doxycycline (100 mg) dinten saméméhna, sanggeus ngalakukeun perlakuan laser picosecond pikeun parut jarawat. Taun kamari, anjeunna ngalaman masalah anu sarua di tempat anu sarua sanggeus nyandak dosis doxycycline post‑laser nu sarua. Anjeunna teu boga riwayat médis anu signifikan sarta teu aya gejala séjén, kawas muriang, boh sacara lokal atawa sapanjang awakna.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) sareng toxic epidermal necrolysis (TEN) mangrupikeun dua bentuk réaksi kulit anu serius, béda ti kaayaan kulit séjén sapertos erythema multiforme major sareng sindrom kulit scalded staphylococcal, ogé réaksi narkoba. SJS/TEN mangrupa réaksi langka jeung parna nu ngabalukarkeun karusakan kulit jeung mémbran mukosa sacara nyebar, mindeng dibarengan ku gejala sistemik. Dina leuwih ti 80 % kasus, pangobatan nyaéta panyabab utama.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Erupsi ubar didiagnosa utamina dumasar kana riwayat médis jeung pamariksaan klinis. Biopsi kulit, tés getih, atawa tés imunologis ogé tiasa mangpaat.
Conto ubar umum anu nyababkeun letusan nyaéta antibiotik jeung obat antimikroba séjén, obat sulfa, obat anti radang nonsteroid (NSAID), agén kémoterapi pikeun kanker, antikonvulsan, jeung obat psikotropika.
○ Diagnosis sareng Perawatan
Upami anjeun gaduh muriang (naékna suhu awak), anjeun kudu néangan perhatian médis pas mungkin. Ubar nu disangka kudu dihentikan (sapertos antibiotik, obat anti radang nonsteroid). Sateuacan nganjang ka rumah sakit, antihistamin lisan sapertos cetirizine atanapi loratadine tiasa ngabantosan gatel jeung ruam.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Tés getih (CBC, LFT, jumlah eosinofil)
Stéroid lisan jeung antihistamin kalayan resep dokter